Indian Journal of Transplantation

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 15  |  Issue : 3  |  Page : 227--231

Tacrolimus therapeutic drug monitoring and correlation with clinical events – A single-center prospective study


Mayoor V Prabhu1, Akash Nayak Karopadi2, Sreepada V Subhramanyam3, B. H. Santhosh Pai4, KS Nayak5 
1 Department of Nephrology, Kasturba Medical College, Mangalore (Manipal Academy of Higher Education, Manipal), India
2 Management Consulting Division, Alira Health GmbH, Munich, Germany
3 Department of Nephrology, Deccan Hospital, Hyderabad, Telangana, India
4 Department of Nephrology, Yenepoya Medical College, (Yenepoya Deemed to be University, Mangalore), India
5 Department of Nephrology, Virinchi Hospital, Hyderabad, Telangana, India

Correspondence Address:
Dr. B. H. Santhosh Pai
Department of Nephrology, Yenepoya Medical College, Yenepoya Deemed to be University, Mangalore, Karnataka
India

Background: Tacrolimus exposure is estimated by trough levels (C0). Recent studies suggest that C0 may not accurately reflect the area under the curve (AUC) and may not correlate with clinical events like acute rejection (AR) and nephrotoxicity. Materials and Methods: In an open, prospective, single-center study, 29 consecutive recipients of renal transplantation underwent C0 along with 2-h (C2), 4-h (C4), and 6-h (C6) estimation of blood tacrolimus levels by enzyme-linked immunosorbent assay, 72 h after initiation with tacrolimus or after a change in its dosage. AUC was estimated by trapezoidal method. C0, C2, C4, and C6 levels were correlated with the AUC. Results: Thirty-six AUC estimations were made over a 2-year period. The best correlate was C6. Correlation coefficients were C0 – 0.868, C2 – 0.788, C4 – 0.839, and C6 – 0.904. C6 values accounted for 79% of the variability of the AUC. Six patients experienced AR, with 5 having C0 within the target range. C6 values correlated best with AUC in these patients (C0 – 0.970, C2 – 0.833, C4 – 0.942, and C6 – 0.970). This was statistically significant. Three patients developed tacrolimus toxicity. In these patients, the correlation coefficients were C0 – 0.551, C2 – 0.556, C4 – 0.77, and C6 – 0.941. By regression analysis, we developed predictive equations. The equation AUC = 12.126 + 2.81 × C0 + 2.92 × C6 best predicted the AUC. Conclusions: Overall C6 levels were more predictive of the AUC, accurately predicting AR and nephrotoxicity. Incorporating C6 may improve tacrolimus therapeutic drug monitoring.


How to cite this article:
Prabhu MV, Karopadi AN, Subhramanyam SV, Pai BH, Nayak K S. Tacrolimus therapeutic drug monitoring and correlation with clinical events – A single-center prospective study.Indian J Transplant 2021;15:227-231


How to cite this URL:
Prabhu MV, Karopadi AN, Subhramanyam SV, Pai BH, Nayak K S. Tacrolimus therapeutic drug monitoring and correlation with clinical events – A single-center prospective study. Indian J Transplant [serial online] 2021 [cited 2022 Dec 6 ];15:227-231
Available from: https://www.ijtonline.in/article.asp?issn=2212-0017;year=2021;volume=15;issue=3;spage=227;epage=231;aulast=Prabhu;type=0