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Year : 2021  |  Volume : 15  |  Issue : 4  |  Page : 346-350

Kidney transplantation in sensitized patients: Two case reports

Department of Nephrology and Organ Transplantation, New ERA Hospital and Research Institute; Department of Nephrology, Orange City Hospital and Research Institute, Nagpur, Maharashtra, India

Correspondence Address:
Dr. Shivnarayan J Acharya
203, Aum Ganga Apartment, 120, Farm Land, Ramdaspeth, Nagpur - 440 010, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijot.ijot_4_21

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Dreaded complication of kidney transplantation in a sensitized patient is hyper-acute rejection immediately after vascular anastomosis. Although pretransplant complement-dependent cytotoxic cross match (CDC) has been the gold standard for many years, this assay is not perfect. The Luminex-based anti-HLA antibody detection assay is more sensitive and specific. While performing live-related kidney transplantation, luminex cross match is routinely performed but in a situation like deceased donor transplantation, in view of time constraints, we do CDC cross match and go ahead with transplantation if the result is negative (Cell lysis <10%). Here, we present two cases of deceased donor transplantation where CDC cross match was negative, based on this report, we went ahead with kidney transplantation but report of Luminex cross match turned out to be positive after the transplantation was already over. Both the recipients had the features of hyper acute rejection. One patient could be salvaged but the other lost the graft.

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